I noticed a large amount of transactions on the relay servers and the database. The shear volume caused many failed transactions and deadlocks in the database. After digging into the logs, I noticed they were generated by the removable disk security, which was turned off at the time.
In the images below the logging status is displayed together with a sample of the logging generated in a 10.000 seat environment.
The issue is resolved by RES in the Workspace Manager 2012 SR4 revision 8 update, which can be downloaded from the RES Website.
Tags: RES, Workspace Manager, Performance, Logging, Database, Relay Server, Fixed